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Gene Expression Literature Summary
Assay
Age
Western blot
14.5 DPC

15 matching records from 15 references.

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available
Cdkn1b  cyclin dependent kinase inhibitor 1B   (Synonyms: p27, p27Kip1)
Results  Reference
1*J:108720 Berthet C, Klarmann KD, Hilton MB, Suh HC, Keller JR, Kiyokawa H, Kaldis P, Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell. 2006 May;10(5):563-73
1J:329929 Chen G, Yu B, Tan S, Tan J, Jia X, Zhang Q, Zhang X, Jiang Q, Hua Y, Han Y, Luo S, Hoekzema K, Bernier RA, Earl RK, Kurtz-Nelson EC, Idleburg MJ, Madan-Khetarpal S, Clark R, Sebastian J, Fernandez-Jaen A, Alvarez S, King SD, Ramos LL, Santos MLS, Martin DM, Brooks D, Symonds JD, Cutcutache I, Pan Q, Hu Z, Yuan L, Eichler EE, Xia K, Guo H, GIGYF1 disruption associates with autism and impaired IGF-1R signaling. J Clin Invest. 2022 Oct 3;132(19):e159806
1J:266104 Choi JH, Jo HS, Lim S, Kim HT, Lee KW, Moon KH, Ha T, Kwak SS, Kim Y, Lee EJ, Joe CO, Kim JW, mTORC1 accelerates retinal development via the immunoproteasome. Nat Commun. 2018 Jun 27;9(1):2502
1*J:243500 Clement O, Hemming IA, Gladwyn-Ng IE, Qu Z, Li SS, Piper M, Heng JI, Rp58 and p27kip1 coordinate cell cycle exit and neuronal migration within the embryonic mouse cerebral cortex. Neural Dev. 2017 May 15;12(1):8
1J:77297 Di Cunto F, Imarisio S, Hirsch E, Broccoli V, Bulfone A, Migheli A, Atzori C, Turco E, Triolo R, Dotto GP, Silengo L, Altruda F, Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron. 2000 Oct;28(1):115-27
1J:189076 Godin JD, Thomas N, Laguesse S, Malinouskaya L, Close P, Malaise O, Purnelle A, Raineteau O, Campbell K, Fero M, Moonen G, Malgrange B, Chariot A, Metin C, Besson A, Nguyen L, p27(Kip1) Is a Microtubule-Associated Protein that Promotes Microtubule Polymerization during Neuron Migration. Dev Cell. 2012 Oct 16;23(4):729-44
1J:249644 Khalfallah O, Jarjat M, Davidovic L, Nottet N, Cestele S, Mantegazza M, Bardoni B, Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis. Stem Cells. 2017 Feb;35(2):374-385
1*J:124353 Landis MW, Brown NE, Baker GL, Shifrin A, Das M, Geng Y, Sicinski P, Hinds PW, The LxCxE pRb interaction domain of cyclin D1 is dispensable for murine development. Cancer Res. 2007 Aug 15;67(16):7613-20
1J:166796 Park J, Oh Y, Yoo L, Jung MS, Song WJ, Lee SH, Seo H, Chung KC, Dyrk1A phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. J Biol Chem. 2010 Oct 8;285(41):31895-906
1J:219859 Pucilowska J, Vithayathil J, Tavares EJ, Kelly C, Karlo JC, Landreth GE, The 16p11.2 deletion mouse model of autism exhibits altered cortical progenitor proliferation and brain cytoarchitecture linked to the ERK MAPK pathway. J Neurosci. 2015 Feb 18;35(7):3190-200
1J:206951 Sun C, Zhao J, Jin Y, Hou C, Zong W, Lu T, Li H, Gao J, PTEN regulation of the proliferation and differentiation of auditory progenitors through the PTEN/PI3K/Akt-signaling pathway in mice. Neuroreport. 2014 Feb 12;25(3):177-83
1J:211957 Tane S, Ikenishi A, Okayama H, Iwamoto N, Nakayama KI, Takeuchi T, CDK inhibitors, p21(Cip1) and p27(Kip1), participate in cell cycle exit of mammalian cardiomyocytes. Biochem Biophys Res Commun. 2014 Jan 17;443(3):1105-9
1J:320759 Yamauchi Y, Nita A, Nishiyama M, Muto Y, Shimizu H, Nakatsumi H, Nakayama KI, Skp2 contributes to cell cycle progression in trophoblast stem cells and to placental development. Genes Cells. 2020 Jun;25(6):427-438
1*J:285853 Zhang S, Song Z, An L, Liu X, Hu XW, Naz A, Zhou R, Guo X, He L, Zhu H, WD40 repeat and FYVE domain containing 3 is essential for cardiac development. Cardiovasc Res. 2019 Jul 1;115(8):1320-1331
1J:44526 Zindy F, Soares H, Herzog KH, Morgan J, Sherr CJ, Roussel MF, Expression of INK4 inhibitors of cyclin D-dependent kinases during mouse brain development. Cell Growth Differ. 1997 Nov;8(11):1139-50

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/07/2024
MGI 6.23
The Jackson Laboratory